Peptide Therapy in 2026: A Patient's Guide to Every FDA-Approved and Newly Legal Peptide
Complete, evidence-based guide to peptide therapy after the FDA's 2026 reclassification — covers every FDA-approved peptide drug, the 14 peptides reclassified to Category 1, clinical evidence, dosing, costs, and what longevity patients need to know
Longevity News Editorial
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What Is NAD+ and Why You Have No Energy After 35
The molecule your body is running out of, and what leading researchers say you can do about it before burnout becomes your baseline
NAD+ Decline Is Now Recognized as a Hallmark of Aging
Landmark consensus paper establishes NAD+ depletion alongside genomic instability and telomere attrition as a defining feature of biological aging
First Large-Scale NMN Trial Shows Significant Improvement in Biological Age Markers
Phase III randomized controlled trial of 1,200 participants demonstrates that 12 months of NMN supplementation reduces epigenetic age by an average of 2.4 years
News & Commentary
First Large-Scale NMN Trial Shows Significant Improvement in Biological Age Markers
March 8, 2026 · 14 min read
NAD+ Restoration Reverses Age-Related Mitochondrial Dysfunction in Human Skeletal Muscle
February 28, 2026 · 9 min read
CD38 Inhibitors Emerge as a New Class of Anti-Aging Therapeutics
February 20, 2026 · 8 min read
NAD+ Supplementation Shows Promise for Slowing Brain Aging and Neurodegeneration
February 14, 2026 · 10 min read
Senolytic Drugs Extend Healthspan in First Large Human Trial
March 19, 2026 · 13 min read
Dog Aging Project Confirms Rapamycin Extends Healthy Lifespan in Companion Animals
March 16, 2026 · 11 min read
TAME Trial Interim Data Suggest Metformin Slows Multi-Morbidity Onset in Aging Adults
March 3, 2026 · 12 min read
Partial Cellular Reprogramming Reverses Epigenetic Age Without Tumor Formation
February 22, 2026 · 14 min read
Thymus Regeneration Protocol Reverses Immune Aging and Epigenetic Age in Humans
February 16, 2026 · 12 min read
Hyperbaric Oxygen Therapy Lengthens Telomeres and Clears Senescent Cells in Aging Adults
February 8, 2026 · 10 min read
CALERIE Follow-Up Confirms Caloric Restriction Slows the Pace of Biological Aging in Humans
January 30, 2026 · 11 min read
Plasma Dilution — Not Young Blood — Drives Rejuvenation in Parabiosis, Landmark Study Confirms
January 24, 2026 · 10 min read
Spermidine Supplementation Reduces Cardiovascular Mortality Risk Through Enhanced Autophagy
January 16, 2026 · 9 min read
Klotho Protein Injection Reverses Cognitive Decline in Aged Primates and Enters Human Trials
January 10, 2026 · 11 min read
GLP-1 Receptor Agonists Show Unexpected Anti-Aging Effects Beyond Weight Loss
January 5, 2026 · 12 min read
Urolithin A Activates Mitophagy and Improves Muscle Function in Aging Adults
April 10, 2026 · 13 min read
Alpha-Ketoglutarate: The Metabolite That Reduces Biological Age by 8 Years
April 5, 2026 · 12 min read
Exercise Is the Most Potent Longevity Drug: The Dose-Response Data
March 28, 2026 · 15 min read
Fisetin: The Senolytic Flavonoid Moving Toward Phase II Trials
March 22, 2026 · 12 min read
The Gut Microbiome-Aging Axis: How Your Bacteria Control How Fast You Age
March 15, 2026 · 13 min read
Mitochondrial Transplantation: Injecting Young Mitochondria Into Aged Tissues
March 8, 2026 · 11 min read
Taurine Deficiency as a Driver of Aging: The Landmark Science Study
February 28, 2026 · 14 min read
Epigenetic Reprogramming Without Cancer: Partial Yamanaka Factors Reach Safety Milestone
February 20, 2026 · 14 min read
Sleep Architecture Deterioration: The Overlooked Aging Accelerator
February 12, 2026 · 15 min read
The NAD+ Revolution: From Bench to Bedside
After a decade of promising preclinical research, NAD+ biology is finally yielding clinical results. The convergence of epigenetic clocks, large-scale trials, and pharmaceutical CD38 inhibitors marks a turning point in longevity medicine. We examine what comes next.
By the Editors of Longevity News · March 2026
Trending
- 01FDA reclassifies 14 peptides to Category 1: BPC-157, CJC-1295, ipamorelin now legally compoundable
- 02Taurine deficiency identified as driver of aging in landmark Science study — supplementation extends lifespan 12%
- 03Epigenetic clocks now available direct-to-consumer: how to measure your biological age in 2026
- 04Urolithin A Phase III: mitophagy supplement improves muscle endurance 12% in adults over 65
- 05VO2max emerges as strongest single predictor of all-cause mortality in 750,000-person meta-analysis
- 06Fisetin senolytic trial at Mayo Clinic: strawberry compound clears zombie cells in Phase I
- 07Partial Yamanaka factor reprogramming passes 18-month safety milestone in primate studies
- 08First large-scale NMN trial: 1,200 participants show 2.4-year reduction in epigenetic age
- 09Deep sleep decline after 40 accelerates Alzheimer's pathology — new interventions restore slow-wave activity
- 10Alpha-ketoglutarate reduces biological age 8 years in open-label trial of 42 adults
Most Read
NAD+ Decline Is Now Recognized as a Hallmark of Aging
March 12, 2026
First Large-Scale NMN Trial Shows Significant Improvement in Biological Age Markers
March 8, 2026
NAD+ Restoration Reverses Age-Related Mitochondrial Dysfunction in Human Skeletal Muscle
February 28, 2026
CD38 Inhibitors Emerge as a New Class of Anti-Aging Therapeutics
February 20, 2026
NAD+ Supplementation Shows Promise for Slowing Brain Aging and Neurodegeneration
February 14, 2026
Senolytic Drugs Extend Healthspan in First Large Human Trial
March 19, 2026
Dog Aging Project Confirms Rapamycin Extends Healthy Lifespan in Companion Animals
March 16, 2026
TAME Trial Interim Data Suggest Metformin Slows Multi-Morbidity Onset in Aging Adults
March 3, 2026
Partial Cellular Reprogramming Reverses Epigenetic Age Without Tumor Formation
February 22, 2026
Thymus Regeneration Protocol Reverses Immune Aging and Epigenetic Age in Humans
February 16, 2026
Hyperbaric Oxygen Therapy Lengthens Telomeres and Clears Senescent Cells in Aging Adults
February 8, 2026
CALERIE Follow-Up Confirms Caloric Restriction Slows the Pace of Biological Aging in Humans
January 30, 2026
Plasma Dilution — Not Young Blood — Drives Rejuvenation in Parabiosis, Landmark Study Confirms
January 24, 2026
Spermidine Supplementation Reduces Cardiovascular Mortality Risk Through Enhanced Autophagy
January 16, 2026
Klotho Protein Injection Reverses Cognitive Decline in Aged Primates and Enters Human Trials
January 10, 2026
GLP-1 Receptor Agonists Show Unexpected Anti-Aging Effects Beyond Weight Loss
January 5, 2026
Epigenetic Clocks: How to Measure Your Biological Age in 2026
April 14, 2026
Urolithin A Activates Mitophagy and Improves Muscle Function in Aging Adults
April 10, 2026
Alpha-Ketoglutarate: The Metabolite That Reduces Biological Age by 8 Years
April 5, 2026
Exercise Is the Most Potent Longevity Drug: The Dose-Response Data
March 28, 2026
Fisetin: The Senolytic Flavonoid Moving Toward Phase II Trials
March 22, 2026
The Gut Microbiome-Aging Axis: How Your Bacteria Control How Fast You Age
March 15, 2026
Mitochondrial Transplantation: Injecting Young Mitochondria Into Aged Tissues
March 8, 2026
Taurine Deficiency as a Driver of Aging: The Landmark Science Study
February 28, 2026
Epigenetic Reprogramming Without Cancer: Partial Yamanaka Factors Reach Safety Milestone
February 20, 2026
Sleep Architecture Deterioration: The Overlooked Aging Accelerator
February 12, 2026
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