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FDA reclassifies 14 peptides to Category 1: BPC-157, CJC-1295, ipamorelin now legally compoundableTaurine deficiency identified as driver of aging in landmark Science study — supplementation extends lifespan 12%Epigenetic clocks now available direct-to-consumer: how to measure your biological age in 2026Urolithin A Phase III: mitophagy supplement improves muscle endurance 12% in adults over 65VO2max emerges as strongest single predictor of all-cause mortality in 750,000-person meta-analysisFisetin senolytic trial at Mayo Clinic: strawberry compound clears zombie cells in Phase IPartial Yamanaka factor reprogramming passes 18-month safety milestone in primate studiesFirst large-scale NMN trial: 1,200 participants show 2.4-year reduction in epigenetic ageDeep sleep decline after 40 accelerates Alzheimer's pathology — new interventions restore slow-wave activityAlpha-ketoglutarate reduces biological age 8 years in open-label trial of 42 adultsFDA reclassifies 14 peptides to Category 1: BPC-157, CJC-1295, ipamorelin now legally compoundableTaurine deficiency identified as driver of aging in landmark Science study — supplementation extends lifespan 12%Epigenetic clocks now available direct-to-consumer: how to measure your biological age in 2026Urolithin A Phase III: mitophagy supplement improves muscle endurance 12% in adults over 65VO2max emerges as strongest single predictor of all-cause mortality in 750,000-person meta-analysisFisetin senolytic trial at Mayo Clinic: strawberry compound clears zombie cells in Phase IPartial Yamanaka factor reprogramming passes 18-month safety milestone in primate studiesFirst large-scale NMN trial: 1,200 participants show 2.4-year reduction in epigenetic ageDeep sleep decline after 40 accelerates Alzheimer's pathology — new interventions restore slow-wave activityAlpha-ketoglutarate reduces biological age 8 years in open-label trial of 42 adults
Volume 12, Issue 4 — April 2026 | Special Issue: Peptides, Senolytics & the New Longevity Toolbox

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2,847

Research Articles

156

Clinical Trials Tracked

423

Reviews Published

68.2

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Featured Research

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Molecular autophagy pathway research
Review

Spermidine Supplementation Reduces Cardiovascular Mortality Risk Through Enhanced Autophagy

A 10-year prospective cohort study of 829 participants links higher spermidine intake to a 40% reduction in cardiovascular death, with mechanistic evidence pointing to restored autophagic flux

January 16, 20269 min read
Pharmaceutical molecular research and drug development
Review

GLP-1 Receptor Agonists Show Unexpected Anti-Aging Effects Beyond Weight Loss

Post-hoc analysis of the SELECT trial and new mechanistic data reveal that semaglutide reduces biological age, lowers systemic inflammation, and protects against age-related organ decline independently of weight change

January 5, 202612 min read
Runner training on a mountain trail at sunrise demonstrating cardiovascular fitness
Review

Exercise Is the Most Potent Longevity Drug: The Dose-Response Data

Meta-analyses totaling over 750,000 participants establish VO2max as the single strongest predictor of all-cause mortality — stronger than smoking, diabetes, or hypertension

March 28, 202615 min read

News & Commentary

Molecular structure visualization of CD38 inhibitor
Molecular autophagy pathway research
Pharmaceutical molecular research and drug development
Runner training on a mountain trail at sunrise demonstrating cardiovascular fitness
Peaceful sleeping person in soft blue light representing deep restorative sleep
Editorial

The NAD+ Revolution: From Bench to Bedside

After a decade of promising preclinical research, NAD+ biology is finally yielding clinical results. The convergence of epigenetic clocks, large-scale trials, and pharmaceutical CD38 inhibitors marks a turning point in longevity medicine. We examine what comes next.

By the Editors of Longevity News · March 2026

Trending

  1. 01FDA reclassifies 14 peptides to Category 1: BPC-157, CJC-1295, ipamorelin now legally compoundable
  2. 02Taurine deficiency identified as driver of aging in landmark Science study — supplementation extends lifespan 12%
  3. 03Epigenetic clocks now available direct-to-consumer: how to measure your biological age in 2026
  4. 04Urolithin A Phase III: mitophagy supplement improves muscle endurance 12% in adults over 65
  5. 05VO2max emerges as strongest single predictor of all-cause mortality in 750,000-person meta-analysis
  6. 06Fisetin senolytic trial at Mayo Clinic: strawberry compound clears zombie cells in Phase I
  7. 07Partial Yamanaka factor reprogramming passes 18-month safety milestone in primate studies
  8. 08First large-scale NMN trial: 1,200 participants show 2.4-year reduction in epigenetic age
  9. 09Deep sleep decline after 40 accelerates Alzheimer's pathology — new interventions restore slow-wave activity
  10. 10Alpha-ketoglutarate reduces biological age 8 years in open-label trial of 42 adults

Most Read

Pharmaceutical molecular research and drug development
Review

GLP-1 Receptor Agonists Show Unexpected Anti-Aging Effects Beyond Weight Loss

January 5, 2026

Runner training on a mountain trail at sunrise demonstrating cardiovascular fitness
Review

Exercise Is the Most Potent Longevity Drug: The Dose-Response Data

March 28, 2026

Peaceful sleeping person in soft blue light representing deep restorative sleep
Review

Sleep Architecture Deterioration: The Overlooked Aging Accelerator

February 12, 2026

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Journal Metrics

Impact Factor68.2
5-Year IF72.1
Immediacy Index14.8
Eigenfactor0.892
CiteScore98.4