Research Article
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156
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423
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NAD+ Restoration Reverses Age-Related Mitochondrial Dysfunction in Human Skeletal Muscle
Biopsy-confirmed evidence that boosting NAD+ levels rejuvenates mitochondrial bioenergetics in older adults, restoring oxidative phosphorylation capacity to levels seen in individuals 20 years younger
Partial Cellular Reprogramming Reverses Epigenetic Age Without Tumor Formation
Cyclic expression of Yamanaka factors rejuvenates aged tissues in mice, restoring youthful gene expression and organ function while maintaining cellular identity
Hyperbaric Oxygen Therapy Lengthens Telomeres and Clears Senescent Cells in Aging Adults
Repeated hyperbaric oxygen sessions produce a 20% increase in telomere length and 37% reduction in senescent T cells, effects previously only seen with genetic or pharmacological interventions
News & Commentary
NAD+ Restoration Reverses Age-Related Mitochondrial Dysfunction in Human Skeletal Muscle
February 28, 2026 · 9 min read
Partial Cellular Reprogramming Reverses Epigenetic Age Without Tumor Formation
February 22, 2026 · 14 min read
Hyperbaric Oxygen Therapy Lengthens Telomeres and Clears Senescent Cells in Aging Adults
February 8, 2026 · 10 min read
CALERIE Follow-Up Confirms Caloric Restriction Slows the Pace of Biological Aging in Humans
January 30, 2026 · 11 min read
Plasma Dilution — Not Young Blood — Drives Rejuvenation in Parabiosis, Landmark Study Confirms
January 24, 2026 · 10 min read
Fisetin: The Senolytic Flavonoid Moving Toward Phase II Trials
March 22, 2026 · 12 min read
The Gut Microbiome-Aging Axis: How Your Bacteria Control How Fast You Age
March 15, 2026 · 13 min read
Mitochondrial Transplantation: Injecting Young Mitochondria Into Aged Tissues
March 8, 2026 · 11 min read
Taurine Deficiency as a Driver of Aging: The Landmark Science Study
February 28, 2026 · 14 min read
The NAD+ Revolution: From Bench to Bedside
After a decade of promising preclinical research, NAD+ biology is finally yielding clinical results. The convergence of epigenetic clocks, large-scale trials, and pharmaceutical CD38 inhibitors marks a turning point in longevity medicine. We examine what comes next.
By the Editors of Longevity News · March 2026
Trending
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- 04Urolithin A Phase III: mitophagy supplement improves muscle endurance 12% in adults over 65
- 05VO2max emerges as strongest single predictor of all-cause mortality in 750,000-person meta-analysis
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- 07Partial Yamanaka factor reprogramming passes 18-month safety milestone in primate studies
- 08First large-scale NMN trial: 1,200 participants show 2.4-year reduction in epigenetic age
- 09Deep sleep decline after 40 accelerates Alzheimer's pathology — new interventions restore slow-wave activity
- 10Alpha-ketoglutarate reduces biological age 8 years in open-label trial of 42 adults
Most Read
Partial Cellular Reprogramming Reverses Epigenetic Age Without Tumor Formation
February 22, 2026
Hyperbaric Oxygen Therapy Lengthens Telomeres and Clears Senescent Cells in Aging Adults
February 8, 2026
CALERIE Follow-Up Confirms Caloric Restriction Slows the Pace of Biological Aging in Humans
January 30, 2026
Plasma Dilution — Not Young Blood — Drives Rejuvenation in Parabiosis, Landmark Study Confirms
January 24, 2026
Fisetin: The Senolytic Flavonoid Moving Toward Phase II Trials
March 22, 2026
The Gut Microbiome-Aging Axis: How Your Bacteria Control How Fast You Age
March 15, 2026
Mitochondrial Transplantation: Injecting Young Mitochondria Into Aged Tissues
March 8, 2026
Taurine Deficiency as a Driver of Aging: The Landmark Science Study
February 28, 2026
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